"The authors also note that 3D printing represents a loss of control…

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https://reason.com/archives/2018/06/12/you-can-soon-manufacture-anything/
"The authors also note that 3D printing represents a loss of control by government officials. Five years after the creation of the first 3D-printed firearm by Cody Wilson, the RAND authors see technology continuing to re-balance the power relationship between individuals and the state.

"At the domestic level, point-of-sale consumption will no longer be an opportunity for governmental control of risky goods, such as firearms and drones," they write. "State sovereignty is predicated on a monopoly of force and, at a minimum, the capacity to regulate arms. [Additive manufacturing] will further relax this control, giving private citizens greater access to lethal weapons and other tools of violence."

Not mentioned in the report, but noted in a related RAND article, is "the potential for new street drugs, custom-printed from chemicals."

https://reason.com/archives/2018/06/12/you-can-soon-manufacture-anything/