---
title: "Good news, everyone! "Human leukocyte antigen (HLA)-independent, T…"
date: 2020-02-23
source: facebook
type: Archer T. Ships shared a link.
---

# Good news, everyone! "Human leukocyte antigen (HLA)-independent, T…

*February 23, 2020 · Facebook*

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[https://www.nature.com/articles/s41590-019-0578-8](https://www.nature.com/articles/s41590-019-0578-8){target="_blank"}
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Good news, everyone!\
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\"Human leukocyte antigen (HLA)-independent, T cell--mediated targeting of cancer cells would allow immune destruction of malignancies in all individuals. Here, we use genome-wide CRISPR--Cas9 screening to establish that a T cell receptor (TCR) recognized and killed most human cancer types via the monomorphic MHC class I-related protein, MR1, while remaining inert to noncancerous cells. Unlike mucosal-associated invariant T cells, recognition of target cells by the TCR was independent of bacterial loading. Furthermore, concentration-dependent addition of vitamin B-related metabolite ligands of MR1 reduced TCR recognition of cancer cells, suggesting that recognition occurred via sensing of the cancer metabolome. An MR1-restricted T cell clone mediated in vivo regression of leukemia and conferred enhanced survival of NSG mice. TCR transfer to T cells of patients enabled killing of autologous and nonautologous melanoma. These findings offer opportunities for HLA-independent, pan-cancer, pan-population immunotherapies.\"\
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[https://www.nature.com/articles/s41590-019-0578-8](https://www.nature.com/articles/s41590-019-0578-8){target="_blank"}
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