"In the study, 42 participants completed a battery of psychology…

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https://www.psypost.org/2019/09/a-single-dose-of-5-meo-dmt-produces-rapid-and-persistent-improvements-in-life-satisfaction-and-psychopathological-symptoms-54486
"In the study, 42 participants completed a battery of psychology tests before inhaling vapor from dried toad secretion containing 5-MeO-DMT. The participants completed the tests again about 24 hours later and 24 participants completed the tests yet again at a 4-week follow-up assessment.

“This study was a so-called ‘naturalistic observational study.’ This means that as a researcher, I simply observed what was occurring at sessions where toad secretion containing 5-MeO-DMT was administered to participants by facilitators, and distributed questionnaires to the participants,” Uthaug explained.

“Although there are limitations with this design (no placebo-control, participant bias, etc), it has an advantage in the sense that it allows researchers to get a better look at drug effects than what the current legality status of psychedelics permit.”

The researchers found that subjective ratings of life satisfaction, depression, anxiety, and mindfulness improved on the day after the session, and this effect persisted for four weeks. The findings are in line with a previous survey of 362 adults, which found that approximately 80& of respondents reported improvements in anxiety and depression after using 5-MeO-DMT."

https://www.psypost.org/2019/09/a-single-dose-of-5-meo-dmt-produces-rapid-and-persistent-improvements-in-life-satisfaction-and-psychopathological-symptoms-54486