"The key to increasing energy expenditure without exercise is to promote the activity of what are called brown and beige adipocytes, or fat cells, in a process called non-shivering thermogenesis.
Insulin and leptin act on a part of the hypothalamus in the brain to increase this brown and beige fat activity, and to decrease appetite.
In this study, Professor Tiganis’ team reveal that elevated levels of two enzymes, called PTP1B and TCPTP, dampen the effects of leptin and insulin, leading to the development and maintenance of obesity in mice.
When the researchers blocked the activity of these two enzymes, this increased insulin and leptin activity, which reduced appetite and increased activity of brown and beige fat cells.
Essentially, blocking these two enzymes led to significant weight loss and improved metabolism despite a high fat diet.
The researchers used a daily dose of a combination of drugs, administered as a nasal spray. These drugs are known to inhibit these enzymes, leading to weight loss and the maintenance of this weight loss.
One of the drugs used, RU486, is used as a contraceptive pill, and is also in clinical trials for the treatment of the metabolic disorder Cushing’s syndrome. The other drug has been trialled for the treatment of type 2 diabetes."
https://scienceblog.com/510655/nasal-spray-could-help-control-appetite-burn-fat-and-reduce-weight/
Insulin and leptin act on a part of the hypothalamus in the brain to increase this brown and beige fat activity, and to decrease appetite.
In this study, Professor Tiganis’ team reveal that elevated levels of two enzymes, called PTP1B and TCPTP, dampen the effects of leptin and insulin, leading to the development and maintenance of obesity in mice.
When the researchers blocked the activity of these two enzymes, this increased insulin and leptin activity, which reduced appetite and increased activity of brown and beige fat cells.
Essentially, blocking these two enzymes led to significant weight loss and improved metabolism despite a high fat diet.
The researchers used a daily dose of a combination of drugs, administered as a nasal spray. These drugs are known to inhibit these enzymes, leading to weight loss and the maintenance of this weight loss.
One of the drugs used, RU486, is used as a contraceptive pill, and is also in clinical trials for the treatment of the metabolic disorder Cushing’s syndrome. The other drug has been trialled for the treatment of type 2 diabetes."
https://scienceblog.com/510655/nasal-spray-could-help-control-appetite-burn-fat-and-reduce-weight/