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"Though refrigeration capacity varies from location to location, vaccines are only cleared for 30 days of storage in the most common units (including those in which they have been shipped). States have been rushing to build out their storage capacity, but have been warned of monthslong waits for ultracold freezers that could extend shelf life to about six months.

That means that, in many places, this first batch of vaccine is set to expire in late January
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Presumably, the American pace will accelerate somewhat even before then. But on the current pace, by that point about 6 million Americans — perhaps 10 million — would have been vaccinated. And, depending on local bureaucracy and storage capacity, perhaps many million doses will be set to expire."