| Medical Research | Howard Hughes Medical Institute | US nonprofit funding frontier biomedical research through its own laboratories and investigator program, spending $900M+ annually. | hhmi.org | @HHMINews |
| Medical Research | Wellcome Trust | UK-based charitable foundation funding health research globally with a $35B+ endowment; the world's largest charitable funder of biomedical science. | wellcome.org | @wellcometrust |
| Medical Research | Chan Zuckerberg Initiative | Philanthropic LLC funding science and education with a stated goal of curing all disease by 2100 through basic science infrastructure funding. | chanzuckerberg.com | @ChanZuckerberg |
| Mathematics and Physical Sciences | Simons Foundation | Private foundation funding research in mathematics, physics, and life sciences including the Flatiron Institute and SFARI autism research program. | simonsfoundation.org | @SimonsFdn |